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Volume 8 Issue 12, December 2007

From The Editors

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Research Highlight

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In the News

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Research Highlight

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In Brief

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Research Highlight

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In Brief

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Research Highlight

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Progress

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Review Article

  • Membrane phosphoinositides are important for generating key intracellular second messengers and are also able to directly regulate the activity of membrane proteins. Gamper and Shapiro discuss the regulatory actions of phosphoinositides on a range of neuronal ion channels and transporters.

    • Nikita Gamper
    • Mark S. Shapiro
    Review Article
  • It has become apparent that, in addition to removing excess extracellular glutamate, glutamate transporters can help to shape synaptic events. Tzingounis and Wadiche review the structural properties and regulation of glutamate transporters, highlighting their diverse roles in key brain regions.

    • Anastassios V. Tzingounis
    • Jacques I. Wadiche
    Review Article
  • Post-translational protein modification can modulate neuronal activity and function. Here, Henley and colleagues discuss the emerging data on the roles of protein SUMOylation in various aspects of nervous-system function and in the pathology of several neurological disorders.

    • Stéphane Martin
    • Kevin A. Wilkinson
    • Jeremy M. Henley
    Review Article
  • Darwin saw the evolution of the vertebrate eye as one of the biggest challenges for his theory. Lamb and colleagues integrate molecular and morphological evidence across different taxa and propose a sequence of evolutionary steps through which the vertebrate eye might have emerged.

    • Trevor D. Lamb
    • Shaun P. Collin
    • Edward N. Pugh Jr
    Review Article
  • Semantic memory is thought to be structured as a widely distributed brain network that contains information regarding modality-specific features. Here, Patterson and colleagues discuss the idea, based on neuropsychological and neuroimaging data and connectionist modelling, that conceptual knowledge also requires an amodal hub.

    • Karalyn Patterson
    • Peter J. Nestor
    • Timothy T. Rogers
    Review Article
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