Table of contents
October 2007 Vol 8 No 10
From the editors
p733 | doi:10.1038/nrn2251
Research Highlights
Neurodegenerative disease: Micromanaging dopamine neurons | PDF (362 KB)
p735 | doi:10.1038/nrn2246
Memory: ZIPping erases memories | PDF (211 KB)
p736 | doi:10.1038/nrn2240
In brief
Decision making | Molecular neuroscience | Neurodegenerative disease | Psychiatric disorders | PDF (92 KB)
p736 | doi:10.1038/nrn2249
Mirror neurons: Learning to reflect | PDF (437 KB)
p737 | doi:10.1038/nrn2243
Development: Bricks for different houses | PDF (389 KB)
p737 | doi:10.1038/nrn2247
Chemosensation: Sensing sugar in the brain | PDF (125 KB)
p738 | doi:10.1038/nrn2244
Cancer: On the move | PDF (374 KB)
p738 | doi:10.1038/nrn2245
In the news
Body consciousness | PDF (79 KB)
p738 | doi:10.1038/nrn2248
Stem cells: Intrinsically different | PDF (201 KB)
p740 | doi:10.1038/nrn2239
Neurodegenerative disease: Death receptor takes centre stage | PDF (398 KB)
p740 | doi:10.1038/nrn2242
Psychiatric disorders: Modelling compulsive behaviour | PDF (206 KB)
p741 | doi:10.1038/nrn2238
Reviews
A neuroscientist's guide to lipidomics
Daniele Piomelli, Giuseppe Astarita & Rao Rapaka
p743 | doi:10.1038/nrn2233
Lipids function as both structural membrane components and signalling molecules. Piomelli and colleagues review the implications of lipids in neuronal function, discuss the technical challenges in the field and highlight the potential roles of lipid-mediated retrograde signalling at central synapses.
Retinoic acid in the development, regeneration and maintenance of the nervous system
Malcolm Maden
p755 | doi:10.1038/nrn2212
The ability of retinoic acid to reactivate developmental programmes in the adult suggests that it could be important for the induction of regeneration and the treatment of neurodegenerative disorders. In this Review, Malcolm Maden discusses the roles of retinoic acid in the developing and mature nervous system, highlighting its potential therapeutic applications.
Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
Vittorio Calabrese, Cesare Mancuso, Menotti Calvani, Enrico Rizzarelli, D. Allan Butterfield & Anna Maria Giuffrida Stella
p766 | doi:10.1038/nrn2214
Nitric oxide (NO) has multiple physiological functions in the nervous system. Calabrese et al. focus on the neuroprotective and neurotoxic effects of NO and, based on our understanding of NO-mediated pathways, list potential therapeutic strategies for the prevention and treatment of neurodegenerative diseases.
Dendritic mRNA: transport, translation and function
Clive R. Bramham & David G. Wells
p776 | doi:10.1038/nrn2150
Local protein synthesis in dendrites is thought to contribute to local changes in synaptic activity during development and learning. Bramham and Wells review what is known about the regulation of dendritic mRNAs and their function in activity-dependent plasticity.
Neurons and networks in daily rhythms
Erik D. Herzog
p790 | doi:10.1038/nrn2215
Many neurons show daily rhythms in gene expression and electrical activity. Erik Herzog discusses the molecular and cellular events that underlie this rhythmicity, and shows how the robustness and plasticity of the circadian system allow the brain to adapt to environmental conditions.
Perspective
Opinion
Pathologically activated therapeutics for neuroprotection
Stuart A. Lipton
p803 | doi:10.1038/nrn2229
The development of neuroprotective drugs has been hampered by the fact that many drugs interfere with normal brain functions. Stuart Lipton describes strategies for drug development that are based on the principle that drugs should interact with their target only during states of pathological activation.
Correspondence
Correspondence: Therapeutic use of rTMS
Michael C. Ridding & John C. Rothwell
| doi:10.1038/nrn2169-c2
Erratum: Brain potentials reveal unconscious translation during foreign-language comprehension
| doi:10.1038/nrn2241
