Figures and Tables
From the following article:
Pathologically activated therapeutics for neuroprotection
Stuart A. Lipton
Nature Reviews Neuroscience 8, 803-808 (October 2007)
doi:10.1038/nrn2229
Figure 1
Uncompetitive, pathologically activated therapeutic drugs.
Figure 2
Uncompetitive antagonism by memantine.
Figure 3
Relatively fast off-rate of a pathologically activated therapeutic drug.
Figure 4
Targeted delivery of a pathologically activated therapeutic drug.
Figure 5
Activation of a pathologically activated therapeutic (PAT) drug by its target.
Figure 6
Regulation of protein activity by electrophilic pro-drugs.
