Table of contents
April 2006 Vol 7 No 4
From the editors
p251 | doi:10.1038/nrn1892
Research Highlights
Neurodegenerative diseases: Folding failure
p252 | doi:10.1038/nrn1890
Addiction: Appetite for drugs
p252 | doi:10.1038/nrn1897
Sensory systems: Connexin's auditory connection
p253 | doi:10.1038/nrn1889
Behavioural neuroscience: Sniff and tell
p253 | doi:10.1038/nrn1893
Behavioural neuroscience: The good, the bad and the amygdala
p254 | doi:10.1038/nrn1891
Neurogenesis: The window of fate
p254 | doi:10.1038/nrn1899
Neurodegenerative disorders: Microglia give amyloid plaques the brush off
p254 | doi:10.1038/nrn1901
Ion channels: Behind closed pores
p256 | doi:10.1038/nrn1894
In the news
Working out for brainy babies
p256 | doi:10.1038/nrn1896
In brief
Behavioural neuroscience | Glia | Sensory systems
p257 | doi:10.1038/nrn1895
Neurological disorders: Keeping pace with ataxia
p258 | doi:10.1038/nrn1898
Neuroimmunology: Damage versus repair
p258 | doi:10.1038/nrn1900
Reviews
Laminating the hippocampus
Eckart Förster, Shanting Zhao & Michael Frotscher
p259 | doi:10.1038/nrn1882
The relatively simple architecture of the hippocampus makes it an ideal model to study cortical lamination. Förster et al. review recent work on the molecular mechanisms that guide the formation of cell and fibre layers in the hippocampus.
Meeting of minds: the medial frontal cortex and social cognition
David M. Amodio & Chris D. Frith
p268 | doi:10.1038/nrn1884
The recent convergence of neuroscience and social psychology has shed fresh light on the neural mechanisms underlying social interaction. Amodio and Frith review anatomical and functional characteristics of the medial frontal cortex, highlighting its central role in social cognitive processing.
Ageing and neuronal vulnerability
Mark P. Mattson & Tim Magnus
p278 | doi:10.1038/nrn1886
Molecular changes that occur during ageing are also seen in neurodegenerative diseases. Mattson and Magnus review the mechanisms by which age-related changes contribute to neuronal vulnerability in these diseases and ways in which adaptive responses might facilitate healthy neural ageing.
The therapeutic potential of monoamine oxidase inhibitors
Moussa B. H. Youdim, Dale Edmondson & Keith F. Tipton
p295 | doi:10.1038/nrn1883
Youdim and colleagues describe how the recent solving of the crystal structures of monoamine oxidase enzymes has increased our understanding of the action of their inhibitors, some of which are now showing therapeutic value in the treatment of neurodegenerative conditions.
Perspectives
Science and society
Neuroscience and legal determination of criminal responsibility
Nigel Eastman & Colin Campbell
p311 | doi:10.1038/nrn1887
The relationship between brain activity and behaviour is an issue of great interest and contention. Eastman and Campbell discuss the differences in the legal and scientific constructs of responsibility, and their implications for the determination of criminal responsibility.
Opinion
Mobilizing the base of neuroscience data: the case of neuronal morphologies
Giorgio A. Ascoli
p318 | doi:10.1038/nrn1885
Data sharing in neuroscience remains relatively rare. Ascoli describes the obstacles that need to be overcome, and highlights the great potential for sharing neuronal morphology data as a starting point to mobilize data sharing in the wider neuroscience community.
