Table of contents
From the editors
p85 | doi:10.1038/nrn1850
Research Highlights
Behavioural neuroscience: Addicted to love
p86 | doi:10.1038/nrn1853
Synaptic plasticity: MeCP2 and memory mechanisms
p87 | doi:10.1038/nrn1854
Neurodegenerative disorders: Proof of delivery
p87 | doi:10.1038/nrn1860
Repair: Talking about regeneration
p88 | doi:10.1038/nrn1851
Neuroeconomics: Decisions, decisions
p88 | doi:10.1038/nrn1856
In the news
Damage limitation
p88 | doi:10.1038/nrn1862
In brief
Development | Synaptic physiology | Neuroimaging
p89 | doi:10.1038/nrn1861
Pain: Thinking pain away
p90 | doi:10.1038/nrn1858
Cortical networks: Dynamic networking
p90 | doi:10.1038/nrn1859
Glia: NMDA receptors on oligodendrocytes
p91 | doi:10.1038/nrn1857
Synaptic plasticity: Capturing the signal
p92 | doi:10.1038/nrn1852
Glia: Essential assemblies
p92 | doi:10.1038/nrn1855
Reviews
Article series: Signalling in Development
Notch signalling in vertebrate neural development
Angeliki Louvi & Spyros Artavanis-Tsakonas
p93 | doi:10.1038/nrn1847
Notch signalling has a key role in many aspects of vertebrate nervous system development. Louvi and Artavanis-Tsakonas review the pleiotropic activity of Notch signalling and discuss challenges in defining the complex genetic circuitry into which Notch is integrated.
Mechanisms of ventral patterning in the vertebrate nervous system
Giuseppe Lupo, William A. Harris & Katharine E. Lewis
p103 | doi:10.1038/nrn1843
Lupo and colleagues review the crucial molecular pathways that regulate ventral patterning of the telencephalon, eye and spinal cord, and show that ventral patterning can be explained by a few basic molecular mechanisms that are conserved along the anterioposterior axis.
The molecular basis for calcium-dependent axon pathfinding
Timothy M. Gomez & James Q. Zheng
p115 | doi:10.1038/nrn1844
Calcium signals have profound and varied effects on growth cone motility and growth. Gomez and Zheng review recent evidence on intracellular calcium signalling pathways, providing fresh insight into how this 'simple' ion can have diverse effects on growth cone behaviours.
Dendritic peptide release and peptide-dependent behaviours
Mike Ludwig & Gareth Leng
p126 | doi:10.1038/nrn1845
Ludwig and Leng review evidence that dendrites are a major source of peptides released in the brain, and that dendritically released peptides can act at distant targets to functionally reorganize neuronal networks, providing a substrate for long-lasting behaviours.
New approaches to antidepressant drug discovery: beyond monoamines
Olivier Berton & Eric J. Nestler
p137 | doi:10.1038/nrn1846
All antidepressants in use today act via the monoamine neurotransmitters. However, only 
50% of individuals with depression show full remission. Berton and Nestler review recent development of alternative, non-monoamine-based antidepressants, highlighting the obstacles and some of the most promising strategies.
Perspectives
Opinion
The Blue Brain Project
Henry Markram
p153 | doi:10.1038/nrn1848
Markram describes the impressive aims of the Blue Brain Project, in which the enormous computing power of IBM's Blue Gene supercomputer is being harnessed to build biologically accurate models of the neocortical column and, ultimately, the whole brain.
Opinion
Dynamics of hemispheric specialization and integration in the context of motor control
Deborah J. Serrien, Richard B. Ivry & Stephan P. Swinnen
p160 | doi:10.1038/nrn1849
The left hemisphere is traditionally thought to be dominant for motor control. However, Serrien and colleagues highlight specialized functions for the right hemisphere and dynamic cross-hemispheric interactions in action processing, particularly emphasizing task- and performer-related demands and time scales.