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Review
Nature Reviews Neuroscience 7, 115–125 (1 February 2006) | doi:10.1038/nrn1844
The molecular basis for calcium-dependent axon pathfinding
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Abstract
Ca2+ signals have profound and varied effects on growth cone motility and guidance. Modulation of Ca2+ influx and release from stores by guidance cues shapes Ca2+ signals, which determine the activation of downstream targets. Although the precise molecular mechanisms that underlie distinct Ca2+-mediated effects on growth cone behaviours remain unclear, recent studies have identified important players in both the regulation and targets of Ca2+ signals in growth cones.
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