Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 7 Issue 10, October 2006

From The Editors

Top of page ⤴

Research Highlight

Top of page ⤴

In Brief

Top of page ⤴

Research Highlight

Top of page ⤴

In the News

Top of page ⤴

Research Highlight

Top of page ⤴

In Brief

Top of page ⤴

Research Highlight

Top of page ⤴

Review Article

  • Voltage-gated ion channels are traditionally considered to solely mediate ion flux. New evidence is emerging that these channels also have important roles in various biological processes that are independent of ion conduction, including neuronal signalling, cell adhesion and gene transcription.

    • Leonard K. Kaczmarek
    Review Article
  • An important pathological feature of polyglutamine repeat diseases involves abnormal interactions between the mutant protein and histone-modifying enzymes, leading to transcriptional dysregulation. Inhibition of these enzymes is therefore a promising therapeutic strategy for Huntington's disease and other polyglutamine repeat disorders.

    • Rachel Butler
    • Gillian P. Bates
    Review Article
  • Cancer induces pain, which often leads to the diagnosis of disease. Mantyh discusses how understanding the mechanisms involved in cancer pain and chemotherapy-induced sensory neuropathy, also associated with pain, might improve the survival and quality of life of cancer patients.

    • Patrick W. Mantyh
    Review Article
Top of page ⤴

Essay

  • It is 100 years since Cajal shared, with Golgi, the Nobel Prize for Physiology or Medicine. Despite the recognition Cajal received for his pioneering studies on the functional organization of the CNS, his fundamental observations on plasticity are less well-known.

    • Javier DeFelipe
    Essay
Top of page ⤴

Opinion

  • Using schizophrenia as an example, Meyer-Lindenberg and Weinberger review the effectiveness of the intermediate phenotype concept for characterizing the neural systems affected by risk gene variants, with a view to elucidating mechanistic aspects of brain function implicated in psychiatric disease.

    • Andreas Meyer-Lindenberg
    • Daniel R. Weinberger
    Opinion
Top of page ⤴

Correspondence

Top of page ⤴

Reply

Top of page ⤴

Search

Quick links