Abstract

A fundamental question in memory research is how our brains can form enduring memories. In humans, memories of everyday life depend initially on the medial temporal lobe system, including the hippocampus. As these memories mature, they are thought to become increasingly dependent on other brain regions such as the cortex. Little is understood about how new memories in the hippocampus are transformed into remote memories in cortical networks. However, recent studies have begun to shed light on how remote memories are organized in the cortex, and the molecular and cellular events that underlie their consolidation.

Author affiliations

1. Programs in Integrative Biology and Brain & Behaviour, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1XB.
2. Department of Physiology and Institute of Medical Science, University of Toronto, Toronto, Canada.
3. Laboratoire de Neurosciences Cognitives, CNRS UMR 5106, Université de Bordeaux 1, Avenue des Facultés, 33405 Talence, France.

Correspondence to: Paul W. Frankland^1,2 Email: paul.frankland@sickkids.ca

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