Figures and Tables
From the following article:
Pathways modulating neural KCNQ/M (Kv7) potassium channels
Patrick Delmas & David A. Brown
Nature Reviews Neuroscience 6, 850-862 (November 2005)
doi:10.1038/nrn1785
Figure 1
Some basic properties of the M current as originally observed in frog sympathetic neurons using twin microelectrode voltage-clamp recording.
Figure 2
Regulation of neuronal firing by the M current, as originally observed in a rat sympathetic neuron using single-microelectrode voltage-clamp recordings.
Figure 3
Structure of Kv7 channels: interaction sites on the carboxy-terminal tail of Kv7.2.
Figure 4
Schematic diagram of the phospholipase C-coupled pathway that links M1 muscarinic acetylcholine receptors to Kv7 channels.
Figure 5
Muscarinic inhibition of the M current is accompanied by hydrolysis of PtdIns(4,5)P2.
Figure 6
Relationship between PtdIns(4,5)P2 hydrolysis and M-current inhibition produced by the muscarinic agonist, oxotremorine-methiodide.
Figure 7
Signalling to Kv7/M channels.
