Abstract

Long-term potentiation and long-term depression are processes that have been widely studied to understand the molecular basis of information storage in the brain. Glutamate receptors are required for the induction and expression of these forms of plasticity, and GABA
(-aminobutyric acid) receptors are involved in their modulation. Recent insights into how these receptors are rapidly moved into and out of synaptic membranes has profound implications for our understanding of the mechanisms of long-term potentiation and long-term depression.

Author affiliations

1. MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK.
2. Brain Research Center and Department of Medicine, Vancouver Hospital and Health Sciences Center, University of British Columbia, Vancouver V6T 1Z3, Canada.
3. National Institutes of Health, 37 Convent Drive, Building 35/Room 3C-1002, MSC 3701, Bethesda, Maryland 20892-3701, USA.

Correspondence to: Graham L. Collingridge^1,2 Email: g.l.collingridge@bris.ac.uk

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