Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Perspective
Nature Reviews Neuroscience 5, 808–812 (1 October 2004) | doi:10.1038/nrn1520
Mechanisms of roof plate formation in the vertebrate CNS
&
Abstract
The roof plate is an embryonic organizing centre that occupies the dorsal midline of the vertebrate neural tube. During early CNS development, the roof plate produces secreted factors, which control the specification and differentiation of dorsal neuronal cell types. An appreciation of the signalling properties of the roof plate has prompted an enhanced interest in this important organizing centre, and several recent studies have begun to illuminate the molecular mechanisms of roof plate development.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
