Perspectives
Nature Reviews Neuroscience 5, 808-812 (October 2004) | doi:10.1038/nrn1520
Opinion: Mechanisms of roof plate formation in the vertebrate CNS
Victor V. Chizhikov1 & Kathleen J. Millen1 About the authors
Abstract
The roof plate is an embryonic organizing centre that occupies the dorsal midline of the vertebrate neural tube. During early CNS development, the roof plate produces secreted factors, which control the specification and differentiation of dorsal neuronal cell types. An appreciation of the signalling properties of the roof plate has prompted an enhanced interest in this important organizing centre, and several recent studies have begun to illuminate the molecular mechanisms of roof plate development.
Author affiliations
- Victor V. Chizhikov and Kathleen J. Millen are at the Department of Human Genetics, University of Chicago, 920 East 58th Street, CLSC 319, Chicago, Illinois 60637, USA. Email: kmillen@genetics.bsd.uchicago.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Achieving neuronal patterning by repressionNature Neuroscience News and Views (01 Oct 2000)
Developmental biology Raising the roofNature News and Views (17 Feb 2000)
RESEARCH
Met-driven invasive growth involves transcriptional regulation of Arhgap12Oncogene Original Article
Bone marrow vs extramedullary relapse of acute leukemia after allogeneic hematopoietic cell transplantation: risk factors and clinical courseBone Marrow Transplantation Original Article
See all 42 matches for Research
