Review
Nature Reviews Neuroscience 4, 727-738 (September 2003) | doi:10.1038/nrn1199
The role of 
-synuclein in Parkinson's disease: insights from animal models
Eleonora Maries1, Biplob Dass2, Timothy J. Collier2, Jeffrey H. Kordower2 & Kathy Steece-Collier2 About the authors
Abstract
The abnormal accumulations of fibrillar 
-synuclein in Lewy bodies and the mutations in the gene for -synuclein in familial forms of Parkinson's disease have led to the belief that this protein has a central role in a group of neurodegenerative diseases known as the synucleinopathies. Our understanding of the biology of -synuclein has increased significantly since its discovery in 1997, and recently developed animal models of the synucleinopathies have contributed to this understanding. The information gleaned from animal models has the potential to provide a framework for continuing the development of rational therapeutic strategies.
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Author affiliations
- Department of Neuroscience, The Chicago Medical School, 3333 Green Bay Road, N. Chicago, Illinois 60064, USA.
- Department of Neurological Sciences, Rush Presbyterian–St. Luke's Medical Center, 2242 W. Harrison Street, Chicago, Illinois 60012, USA.
Correspondence to: Kathy Steece-Collier2 Email: kathy_a_steece-collier@rush.edu
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