Review
Nature Reviews Neuroscience 4, 739-751 (September 2003) | doi:10.1038/nrn1198
There is a Correction (1 December 2003) associated with this article.
The high-conductance state of neocortical neurons in vivo
Alain Destexhe1, Michael Rudolph1 & Denis Paré2 About the authors
Abstract
Intracellular recordings in vivo have shown that neocortical neurons are subjected to an intense synaptic bombardment in intact networks and are in a 'high-conductance' state. In vitro studies have shed light on the complex interplay between the active properties of dendrites and how they convey discrete synaptic inputs to the soma. Computational models have attempted to tie these results together and predicted that high-conductance states profoundly alter the integrative properties of cortical neurons, providing them with a number of computational advantages. Here, we summarize results from these different approaches, with the aim of understanding the integrative properties of neocortical neurons in the intact brain.
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Author affiliations
- Integrative and Computational Neuroscience Unit (UNIC), CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
- Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey 07102, USA.
Correspondence to: Alain Destexhe1 Email: destexhe@iaf.cnrs-gif.fr
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