Review
Nature Reviews Neuroscience 4, 752-762 (September 2003) | doi:10.1038/nrn1197
14-3-3 proteins in the nervous system
Daniela Berg1,2, Carsten Holzmann3 & Olaf Riess1 About the authors
Abstract
14-3-3 proteins are abundantly expressed in the brain and have been detected in the cerebrospinal fluid of patients with different neurological disorders. Although the function of this family of highly conserved proteins is not completely known, recent evidence indicates their involvement in multiple cellular processes. By their interaction with more than 100 binding partners, 14-3-3 proteins modulate the action of proteins that are involved in cell cycle and transcriptional control, signal transduction, intracellular trafficking and regulation of ion channels. The study of some of these interactions is sheding light on the role of 14-3-3 proteins in processes such as apoptosis and neurodegeneration.
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Author affiliations
- Institute for Human Genetics, Department of Medical Genetics, University of Tübingen, Calwerstrasse 7, 72076 Tübingen, Germany.
- Hertie Institute for Brain Research, Röntgenweg 11, 72076 Tübingen, Germany.
- Department of Medical Genetics, University of Rostock, Rembrandtstrasse 16/17, 18057 Rostock, Germany.
Correspondence to: Daniela Berg1,2 Email: daniela.berg@uni-tuebingen.de
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