Review
Nature Reviews Neuroscience 4, 386-398 (May 2003) | doi:10.1038/nrn1102
Focus on: Neurological diseases
Neurobiology of migraine
Daniela Pietrobon1 & Jörg Striessnig2 About the authors
Abstract
Migraine — an episodic headache — affects more than 10% of the general population. Despite recent progress, drug therapy for preventing and treating migraine remains unsatisfactory for many patients. One problem that slows the development of new therapeutic approaches is our limited understanding of migraine neurobiology. Activation of the trigeminovascular system is a central step in the development of migraine. However, two main issues remain incompletely understood: the primary cause of migraine, leading to activation of the trigeminovascular system, and the mechanisms of pain generation after its activation.
- View At a Glance
Author affiliations
- Department of Biomedical Sciences, University of Padova, via G. Colombo 3, 35121 Padova, Italy.
- Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Innsbruck, Peter-Mayr-Str. 1, A-6020, Innsbruck, Austria.
Correspondence to: Daniela Pietrobon1 Email: daniela.pietrobon@unipd.it
|
MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated REFERENCE NEWS AND VIEWS RESEARCH |
2 subunit associated with familial hemiplegic migraine type 2
