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Nature Reviews Neuroscience 4, 923–926 (1 November 2003) | doi:10.1038/nrn1258

The long-term potential of LTP

Robert C. Malenka

Long-term potentiation has captured the attention of neuroscientists for over two decades. It has provided motivation to investigate the detailed mechanisms of synaptic transmission and remains a prime candidate for mediating circuit modifications during development and experience-dependent plasticity. However, much remains to be learned about this fascinating phenomenon, which will certainly continue to entice neuroscientists throughout the twenty-first century.