Review
Nature Reviews Neuroscience 4, 901-909 (November 2003) | doi:10.1038/nrn1245
Monitoring of stored and available fuel by the CNS: implications for obesity
Randy J. Seeley1 & Stephen C. Woods1 About the authors
Abstract
Adult mammals do a masterful job of matching caloric intake to caloric expenditure. To accomplish this, the central nervous system (CNS) must be able to monitor the status of peripheral energy stores and ongoing fuel availability. Recent observations support the hypothesis that ongoing fuel availability can be monitored directly in the CNS by mechanisms that extend beyond the sensing of glucose (the primary neuronal fuel). Questions remain as to how signals from stored and available fuel are integrated, and it will be vital to answer these key neuroscience questions to develop biological therapies to curb the growing human and monetary costs of obesity.
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Author affiliations
- Department of Psychiatry and Obesity Research Center, University of Cincinnati, Cincinnati, Ohio 45267-0559, USA.
Correspondence to: Randy J. Seeley1 Email: Randy.Seeley@uc.edu
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