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Review
Nature Reviews Neuroscience 3, 873–883 (1 November 2002) | doi:10.1038/nrn959
Calcium-dependent inactivation of neuronal calcium channels
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Abstract
Calcium ions are ubiquitous intracellular mediators of numerous cellular processes. One of the main mechanisms of Ca2+ entry into the cell involves the opening of Ca2+ channels in the plasma membrane. To effectively control Ca2+ signalling, Ca2+ channels inactivate rapidly by a mechanism that depends on an elevation of intracellular Ca2+ within tens of nanometres of the channel pore. A structural understanding of this mechanism will provide a framework for understanding the regulation of Ca2+ entry and accumulation in neurons. Recent physiological, biochemical and molecular studies have yielded new insights into the regulation of neuronal Ca2+ channels.
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