Figure 1 | C fibres and the dorsal horn of the spinal cord.   The termination of the two prominent groups of nociceptive C fibres within the dorsal horn of the spinal cord. They differ in their content of peptides and neurotransmitter receptors, and mode and site of termination within the dorsal horn, although they innervate similar peripheral tissues^{1, 17}. (CGRP, calcitonin-gene-related peptide; FRAP, fluoride-resistant acid phosphatase; IB4, IB4-lectin-binding site; P2X3, purine receptor; Ret, glial-cell-derived neurotrophic factor receptor tyrosine kinase; SP, substance P; TrkA, tyrosine receptor kinase A.)

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