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Reconstructing functional systems after lesions of cerebral cortex

Nature Reviews Neuroscience volume 2, pages 911–919 (2001)Cite this article

Abstract

The young brain is enormously resilient to early injury. This resiliency contrasts with the severe and permanent impairments that frequently accompany equivalent damage to the mature cerebrum. For example, damage to Broca's area renders the patient unable to speak, but equivalent damage early in life does not have such devastating effects. Here we review the history of the study of early lesion-induced plasticity, and delineate the features of the developing brain that permit it to overcome the effects of early cerebral lesions. We also speculate on future avenues of investigation that should help us to comprehend how young brains are naturally rebuilt after early lesions.

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Figure 1: Reconstructing motor systems.
Figure 2: Rebuilding a highly functional visual system.
Figure 3: Rebuilding a system after an early lesion.

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Acknowledgements

This work was supported by funds from the National Institute of Neurological Diseases and Stroke.

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Authors and Affiliations

  1. the Department of Anatomy and Neurobiology, Laboratory for Visual Perception and Cognition, Boston University School of Medicine, Boston, 02118, Massachusetts, USA

    Bertram R. Payne

  2. the Cerebral Systems Laboratory, School of Human Development, University of Texas at Dallas, Richardson, 75083, Texas, USA

    Stephen G. Lomber

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  1. Bertram R. Payne
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Correspondence to Bertram R. Payne.

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FURTHER INFORMATION

cortical plasticity: use-dependent remodelling

MIT Encyclopedia of Cognitive Sciences

auditory plasticity

neural plasticity

Bertram Payne's lab

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Payne, B., Lomber, S. Reconstructing functional systems after lesions of cerebral cortex. Nat Rev Neurosci 2, 911–919 (2001). https://doi.org/10.1038/35104085

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