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In a new, chimeric model of Alzheimer disease (AD), in which human neurons were transplanted into an AD mouse model, amyloid-β-related pathology was associated with robust degeneration of the human neurons but no neurofibrillary tangle formation.
Touch neurons inCaenorhabditis eleganseliminate aggregated or neurotoxic proteins and dysfunctional mitochondria by exporting them in large vesicles called exophers.
The experience of controlling our own actions is an important feature of human mental life. The processes giving rise to this experience are thought to be disrupted in some psychiatric disorders. In this article, Haggard describes recent developments in our understanding of the cognitive processes and neural mechanisms underlying the sense of agency.
The circuitry of the hippocampal CA3 region has long been hypothesized to be well suited to the storage of memories. Mulle and colleagues provide an update on the known types and mechanisms of synaptic plasticity in CA3 and describe evidence for their roles in memory formation and retrieval.
Optogenetics is widely used to study the consequences of neuronal activity with high spatiotemporal precision. In this Review, Kimet al. discuss the integration of this approach with other technological and methodological advances to gain insights into neuronal function that were previously inaccessible.
Kinetic models of NMDA receptor activation derived from single-molecule observations explain the biologically salient features of the excitatory current as a dynamic sequence of quasi-stable receptor states. In this Review, Iacobucci and Popescu discuss how these models will help to match emerging atomic structures with biologically important functional states.
The year 2017 marks 200 years since James Parkinson'sAn Essay on the Shaking Palsywas published. In this Timeline article, Serge Przedborski provides an overview of the various avenues of research into Parkinson disease that have been pursued over these two centuries to better understand this neurodegenerative disorder.
