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Volume 15 Issue 5, May 2014

'Tracing the tree' by Jennie Vallis, inspired by the Review on p300

Research Highlight

  • The transcription factor REST has a neuroprotective role in the healthy ageing brain that is disrupted in Alzheimer's disease.

    • Katherine Whalley

    Nature Outlook:

    Research Highlight

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In the News

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Research Highlight

  • Neuronally expressed major histocompatibility complex class I molecule H2-Dbregulates structural and functional plasticity at retinogeniculate synapses.

    • Leonie Welberg
    Research Highlight
  • Activation of microglial complement receptor 3 by an inflammatory stimulus in the presence of hypoxia induces long-term depression of synaptic transmission in the hippocampus.

    • Darran Yates
    Research Highlight
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In Brief

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Research Highlight

  • An event that is experienced from an 'out-of-body' perspective is remembered less well and its recall does not induce the usual pattern of hippocampal activation.

    • Leonie Welberg
    Research Highlight
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In Brief

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Research Highlight

  • Both GABAergic and glutamatergic projections can modulate the strength of electrical coupling between inferior olive neurons and alter neuron synchronization in the cerebellar inferior olive.

    • Leonie Welberg
    Research Highlight
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Review Article

  • JUN amino-terminal kinases (JNKs) regulate various processes in neurodevelopment and the adult brain. In this Review, Coffey examines the neuronal functions of JNKs and the therapeutic potential of targeting these kinases in various diseases of the nervous system.

    • Eleanor T. Coffey
    Review Article
  • Intracortical brain–machine interfaces with sensorimotor cortices are one approach by which a person can exert voluntary control over a prosthetic limb or paralysed muscles. In this Review, Bensmaia and Miller review recent achievements and remaining challenges in the development of intracortical brain–machine interfaces.

    • Sliman J. Bensmaia
    • Lee E. Miller
    Review Article
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Opinion

  • The role of astrocytic Ca2+ signalling in synaptic function remains elusive. In this Opinion article, Volterra and colleagues discuss how recent data reveal an unexpected complexity of Ca2+dynamics in astrocytes, which both challenges current thinking and suggests a new conceptual and experimental framework to address astrocyte function.

    • Andrea Volterra
    • Nicolas Liaudet
    • Iaroslav Savtchouk
    Opinion
  • Bilingualism has attracted attention for its reported effects on linguistic and cognitive abilities. In this Opinion article, Costa and Sebastián-Gallés provide their view on how learning and speaking two languages affects language acquisition and processing as well as executive control processes.

    • Albert Costa
    • Núria Sebastián-Gallés
    Opinion
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