Table of contents

Research Highlights

Learning and memory: Uncoupling memory traces | PDF (733 KB)

p629 | doi:10.1038/nrn3828

The emotional valence of a memory can be changed, and this probably involves a change in the connectivity between hippocampal and amygdalar memory traces.

Learning and memory: Consolidation of fear | PDF (619 KB)

p630 | doi:10.1038/nrn3821

In mice, miR-34a-mediated downregulation of Notch signalling in the basolateral amygdala enables fear memory consolidation.

Psychiatric disorders: Disrupted transmission | PDF (743 KB)

p630 | doi:10.1038/nrn3822

Neurons derived from human induced pluripotent stem cells harbouring a mutation in disrupted in schizophrenia 1 exhibit synaptic deficits.

Learning and memory: Putting limits on learning | PDF (614 KB)

p631 | doi:10.1038/nrn3826

The existing properties of neurons in a network restrict its ability to learn to generate new activity patterns.

Visual processing: Microcircuits unmasked | PDF (626 KB)

p632 | doi:10.1038/nrn3834

In mouse primary visual cortex, subpopulations of layer six principal cells form distinct microcircuits that are involved in visual processing.

An Interview With...

The Kavli prize winners | PDF (690 KB)

p633 | doi:10.1038/nrn3829

Interviews with this year's winners of the Kavli prize in neuroscience, Brenda Milner, John O'Keefe and Marcus Raichle.

In brief

Learning and memory: Childhood problems and solutions | PDF (566 KB)

p630 | doi:10.1038/nrn3823

Pain: Inflammation and pain | PDF (566 KB)

p630 | doi:10.1038/nrn3824

Neurodegenerative disease: Hypermethylation raises AD risk | PDF (566 KB)

p630 | doi:10.1038/nrn3825

Neurological disorders: Telomeres and depression | PDF (552 KB)

p632 | doi:10.1038/nrn3830

Genes and disease: Schwann cells keep axons healthy | PDF (552 KB)

p632 | doi:10.1038/nrn3831

Cellular neurophysiology: Clearing away the debris | PDF (552 KB)

p632 | doi:10.1038/nrn3832

Cognitive neuroscience: Telling the truth, honestly... | PDF (552 KB)

p632 | doi:10.1038/nrn3833



Cation-chloride cotransporters in neuronal development, plasticity and disease

Kai Kaila, Theodore J. Price, John A. Payne, Martin Puskarjov & Juha Voipio

p637 | doi:10.1038/nrn3819

Dynamic regulation of ion concentrations across the cellular membrane is vital for neuronal function. In this article, Kaila and colleagues review the contribution of members of the cation-chloride cotransporters to neuronal signalling, connectivity, plasticity and disease.

Functional organization of the hippocampal longitudinal axis

Bryan A. Strange, Menno P. Witter, Ed S. Lein & Edvard I. Moser

p655 | doi:10.1038/nrn3785

It is commonly thought that the dorsal hippocampus is implicated in memory and spatial navigation and the ventral hippocampus in anxiety-related behaviours. On the basis of gene expression, anatomical and electrophysiology studies, Strange and colleagues propose a new model of hippocampal functional anatomy, in which functional long-axis gradients are superimposed on discrete functional domains.

The neuroscience of prejudice and stereotyping

David M. Amodio

p670 | doi:10.1038/nrn3800

Social prejudices and stereotyping are pervasive and often operate unconsciously. In this Review, David M. Amodio considers the neural basis of prejudice and stereotyping and discusses the processes through which such biases may form, can influence behaviour and are regulated.

Modern network science of neurological disorders

Cornelis J. Stam

p683 | doi:10.1038/nrn3801

The application of network science to several common neurological disorders challenges the idea that these disorders are either 'local' or 'global'. In this Review, Kees Stam proposes a model of hub overload and failure as a possible final common pathway in diverse neurological disorders.