Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
An acetylating agent with fast antidepressant action in rodents acts by increasing the transcription of type 2 metabotropic glutamate receptors in the hippocampus and the prefrontal cortex.
Masculinization of the preoptic area and sexual behaviour depends on a feedforward loop of prostaglandin E2 production that requires microglial activation.
Interactions between two risk loci for Parkinson's disease affect protein sorting in neurons and point towards a possible common pathway to neuropathology in Parkinson's disease.
Memories can sometimes be disrupted by pharmacological intervention during reconsolidation; a new study shows that a prediction error is required for this process.
Myosins II, V and VI are actin-based cytoskeletal motors that have specific pre- and postsynaptic roles. Kneussel and Wagner review their diverse functions, which include the regulation of actin cytoskeleton dynamics in dendritic spines and powering of synaptic cargo transport.
In this Review, Robberecht and Philips provide a comprehensive summary of the current understanding of the causes and mechanisms underlying the pathogenesis of amyotrophic lateral sclerosis (ALS). The emerging phenotypic heterogeneity of this neurodegenerative disease is leading to the concept that the term ALS covers several conditions and not just one disease.
The aquaporins (AQPs) are a family of integral membrane proteins that are involved in water movement across cell membranes. In this Review, Papadopoulos and Verkman examine the roles of AQPs in the functioning of the mammalian nervous system and in various neurological conditions.
Corticostriatal pathways consist of two distinct classes of cortical pyramidal cells: intratelencephalic and pyramidal tract neurons. In this Review, Shepherd explains how changes in the functional properties of these neurons result in an imbalance in activity that contributes to a wide variety of neurological disorders.
Emerging evidence suggests that there is an inverse comorbidity relationship between certain neurological disorders and certain cancers. In this Opinion article, Tabarés-Seisdedos and Rubenstein discuss the evidence for this intriguing association and possible underlying mechanisms.
