TABLE 1 | Cargo transport rates

From the following article:

Axonal transport deficits and neurodegenerative diseases

Stéphanie Millecamps & Jean-Pierre Julien

Nature Reviews Neuroscience 14, 161-176 (March 2013)


CargoesMain directionRate of axonal transport in peripheral nerves*Refs
Proteins and RNA
Membrane proteinsAnterograde2–8 mm per day7
EnzymesAnterograde2–8 mm per day7
NeurofilamentsAnterograde0.2–1 mm per day (0.3–1 μm per second)2,3,7
TauAnterograde0.2–1 mm per day7
TubulinAnterograde0.2–1 mm per day7
ActinAnterograde2–8 mm per day7
mRNAAnterograde20–200 mm per day177
Membrane-bound organelles
MitochondriaBidirectional<50 mm per day (0.4 μm per second in both directions)6
Golgi-derived vesicles (containing neurotransmitters)Anterograde200–400 mm per day7
Neurosecretory granules (containing, for example, hormones or neurotrophic factors)Anterograde50–400 mm per day7
Endosomal recycling vesicles (containing hormones or neurotrophic factors)Retrograde200 mm per day7
LysosomesBidirectional<50 mm per day in both directions (0.3–0.4 μm per second)6
AutophagosomesRetrograde40 mm per day (0.45 μm per second)4
VirusesRetrograde200 mm per day178
Tetanus toxinRetrograde100–400 mm per day (1–5 μm per second)22
Horseradish peroxidiseRetrograde200 mm per day179
*The velocities of cargo movements, where known, are specified in brackets

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