Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
A new study shows that the switch of sonic hedgehog from an attractive to a repulsive signal for commissural axon navigation involves the heparan sulphate proteoglycan glypican 1 and induction of Hedgehog-interacting protein expression.
A new study shows that increased β-calcium/calmodulin-dependent protein kinase type II expression in the lateral habenula is both sufficient and necessary for the expression of depression-like behaviour in rodents.
Two new studies in mice show that fibroblast growth factor 21 acts at the suprachiasmatic nucleus of the hypothalamus and the dorsal vagal complex of the hindbrain to regulate various adaptive responses to nutritional deprivation.
Inhibiting the expression of a histone-binding protein that declines with age in the human dentate gyrus in young mice leads to memory deficits that are similar to those of aged wild-type mice.
Recent studies have shown that the protein p11 (also known as S100A10) has an important role in depression-like behaviour and antidepressant actions. Greengard and colleagues discuss the molecular and cellular mechanisms that may underlie this role.
Thefruitless (fru) gene is a crucial regulator of male courtship behaviour. In this Review, Yamamoto and Koganezawa discuss and integrate findings from molecular, cellular and behavioural studies of fruto provide an understanding of how a single gene can organize such an elaborate behaviour.
In order to make sense of the multitude of acoustic stimuli that surround us in our daily lives, the auditory system needs to be able to assign different sounds to specific sources within the 'auditory scene'. Bizley and Cohen describe how auditory information processing in the cortex categorizes and groups different sounds into 'auditory objects'.
In this Review, Pouladi and colleagues critically examine the strengths and limitations of the currently available animal models of Huntington's disease. By doing so, they aim to facilitate animal model selection in future studies of this progressive neurodegenerative disorder.
Neural insults in conditions such as multiple sclerosis induce changes in the brain's extracellular matrix (ECM) that can inhibit myelin repair. In this Opinion article, Yong and colleagues examine such changes and how the ECM could be targeted to promote remyelination in disease.
Neuroscientific evidence is increasingly offered in court cases, with neuroscientists often acting as expert witnesses. Jones and colleagues discuss the important roles that neuroscientists serve, as well as the potential problems they, as well as judges and jurors, may encounter.
