Table of contents


From the editors

p607 | doi:10.1038/nrn2910

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Research Highlights

Neurodegenerative disease: The missing link | PDF (349 KB)

p608 | doi:10.1038/nrn2904

tau regulates the interaction of postsynaptic density protein 95 (PSD95) with NMDA (N-methyl-D-aspartate) receptors, which are thought to mediate Aβ toxicity.

Neurogenomics: Parental influences run deep | PDF (210 KB)

p609 | doi:10.1038/nrn2899

Genomic imprinting is widespread in the mouse brain and shows sexual dimorphism.

Neurodegenerative disease: microRNAs under threat from LRRK2 | PDF (167 KB)

p609 | doi:10.1038/nrn2906

translational regulation of E2F1 and DP by miRNAs is implicated in LRRK2-mediated pathogenesis in Parkinson's disease.

Neuron–glia interactions: A tunnel signal | PDF (188 KB)

p610 | doi:10.1038/nrn2901

New neurons control, through Slit-Robo signalling, the organization of the glial tubes through which they migrate in the RMS.

Multiple Sclerosis: Putting a dampener on inflammation | PDF (219 KB)

p610 | doi:10.1038/nrn2903

Signalling by metabotropic glutamate receptor 4 counteracts neuroinflammation in a rodent model of multiple sclerosis.

Neuron–glia interactions: Astrocytes in the air | PDF (180 KB)

p610 | doi:10.1038/nrn2905

Astrocytes control breathing through pH-dependent release of ATP.

In brief

Neurotransmitters | Fear | Stem cells | Drug discovery | PDF (158 KB)

p611 | doi:10.1038/nrn2908

Synaptic plasticity: Assertive authorities | PDF (224 KB)

p612 | doi:10.1038/nrn2909

SIRT1 modulates synaptic plasticity through microRNA-dependent regulation of the transcription factor cAMP-responsive element-binding (CREB) protein.

Neuroendocrinology: Housing conditions affect tumour growth | PDF (203 KB)

p613 | doi:10.1038/nrn2902

Mice that experience an enriched environment are more resistant to tumour growth.

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Reviews

Spiking activity propagation in neuronal networks: reconciling different perspectives on neural coding

Arvind Kumar, Stefan Rotter & Ad Aertsen

p615 | doi:10.1038/nrn2886

Reliable propagation of spiking activity in the brain is vital for information processing. Kumar, Rotter and Aertsen now propose that under certain conditions asynchronous and synchronous propagation of spiking activity can co-exist in a modular neuronal network, and they suggest experimental strategies to test this hypothesis.

Central mechanisms of odour object perception

Jay A. Gottfried

p628 | doi:10.1038/nrn2883

The brain encodes representations of smells through the synthesis of different olfactory inputs into a unified whole. Jay Gottfried discusses the central mechanisms of perception of these 'odour objects' and describes the role of the piriform cortex in this process.

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Perspectives

Opinion

The neurobiology of psychedelic drugs: implications for the treatment of mood disorders

Franz X. Vollenweider & Michael Kometer

p642 | doi:10.1038/nrn2884

In this Perspective, Vollenweider and Kometer discuss the clinical potential of psychedelic drugs for the treatment of various psychiatric disorders, and describe the molecular mechanisms by which classical hallucinogens and dissociative anaesthetics affect serotonin and glutamate systems.
An interview with Franz X. Vollenweider for Neuropod is available for download.

Science and society

Socioeconomic status and the brain: mechanistic insights from human and animal research

Daniel A. Hackman, Martha J. Farah & Michael J. Meaney

p651 | doi:10.1038/nrn2897

Socioeconomic status (SES) influences brain development. Farah and colleagues discuss evidence that prenatal factors, parent–child interactions and cognitive stimulation mediate this effect, and consider implications for alleviating SES-related disparities in mental health and academic achievement.