Review

Nature Reviews Neuroscience 11, 316-328 (May 2010) | doi:10.1038/nrn2836
Corrected online: 30 April 2010

There is a Corrigendum (1 June 2010) associated with this article.

Branching out: mechanisms of dendritic arborization

Yuh-Nung Jan1 & Lily Yeh Jan1  About the authors

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Type-specific dendrite morphology is a hallmark of the neuron and has important functional implications in determining what signals a neuron receives and how these signals are integrated. During the past two decades, studies on dendritic arborization neurons in Drosophila melanogaster have started to identify mechanisms of dendrite morphogenesis that may have broad applicability to vertebrate species. Transcription factors, receptor–ligand interactions, various signalling pathways, local translational machinery, cytoskeletal elements, Golgi outposts and endosomes have been identified as contributors to the organization of dendrites of individual neurons and the placement of these dendrites in the neuronal circuitry. Further insight into these mechanisms will improve our understanding of how the nervous system functions and might help to identify the underlying causes of some neurological and neurodevelopmental disorders.

Author affiliations

  1. Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, 1550 4th Street, San Francisco 94158, USA.

Correspondence to: Yuh-Nung Jan1 Email: YuhNung.Jan@ucsf.edu

* On page 317 in box 1 of the above article, we wrote that: "For example, the ubiquitin ligase anaphase-promoting complex specifically regulates axon or dendrite morphogenesis in murine cerebellar granule cells depending on whether it recruits the co-activator cadherin 1 or CDC20 to the complex152, 153." This should have read: "For example, the ubiquitin ligase anaphase-promoting complex specifically regulates axon or dendrite morphogenesis in murine cerebellar granule cells depending on whether it recruits the co-activator fizzy-related protein homologue or CDC20 to the complex152, 153." The authors apologize for this error.

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