Table of contents
June 2009 Vol 10 No 6
From the editors
p391 | doi:10.1038/nrn2663
Research Highlights
Oscillations: Feel the rhythm | PDF (197 KB)
p392 | doi:10.1038/nrn2659
Neurodegenerative disease: NURR1 puts a dampener on inflammation | PDF (151 KB)
p393 | doi:10.1038/nrn2650
In brief
Neuronal migration | Brain networks | Stress | Emotions | PDF (122 KB)
p393 | doi:10.1038/nrn2661
Neuronal migration: You have arrived | PDF (205 KB)
p394 | doi:10.1038/nrn2654
MicroRNA: Keeping an eye on cell death | PDF (172 KB)
p394 | doi:10.1038/nrn2655
In brief
Development | Neuroimmunology | Mirror neurons | Cognitive neuroscience | PDF (125 KB)
p394 | doi:10.1038/nrn2662
Neurogenetics: Common changes in autism | PDF (176 KB)
p395 | doi:10.1038/nrn2658
Neurodevelopmental disorders: A contagious deficit | PDF (142 KB)
p396 | doi:10.1038/nrn2656
Chemical senses: Sniffing out disease | PDF (149 KB)
p396 | doi:10.1038/nrn2657
Focus on: Stress
Reviews
Neural regulation of endocrine and autonomic stress responses
Yvonne M. Ulrich-Lai & James P. Herman
p397 | doi:10.1038/nrn2647
The physiological response to stress is regulated by a complex neurocircuitry that integrates and interprets stress-related and homeostatic information. Ulrich-Lai and Herman describe this circuitry, including its adaptation to chronic stress and its overlap with circuits that underlie memory and reward.
Stress signalling pathways that impair prefrontal cortex structure and function
Amy F. T. Arnsten
p410 | doi:10.1038/nrn2648
Stress affects cognition and increases noradrenaline and dopamine levels in the prefrontal cortex (PFC). Amy Arnsten discusses the intracellular signalling pathways that mediate the effects of these catecholamines on PFC function during acute and chronic stress, focusing on working memory. An interview with Amy Arnsten for Neuropod is available for download.
Stress, memory and the amygdala
Benno Roozendaal, Bruce S. McEwen & Sumantra Chattarji
p423 | doi:10.1038/nrn2651
Stressful events often leave strong memories. Roozendaal and colleagues discuss how stress hormones and neurotransmitters acting in the amygdala mediate this phenomenon at the behavioural and synaptic level, and describe how stress-induced remodelling of amygdala neurons might underlie anxiety.
Effects of stress throughout the lifespan on the brain, behaviour and cognition
Sonia J. Lupien, Bruce S. McEwen, Megan R. Gunnar & Christine Heim
p434 | doi:10.1038/nrn2639
The effects of stress on the brain depend on the age at which the stress occurs. Reviewing data from animal and human studies, Lupien and colleagues discuss why different disorders emerge in individuals exposed to stress at different times in their lives. An interview with Sonia Lupien for Neuropod is available for download.
Psychobiology and molecular genetics of resilience
Adriana Feder, Eric J. Nestler & Dennis S. Charney
p446 | doi:10.1038/nrn2649
Although stress is associated with many physical and mental illnesses, most individuals cope well with it. Feder and colleagues review the factors that underlie stress resilience, showing that it involves adaptive changes in specific neural circuits, neuromodulator levels and molecular pathways.
Perspectives
Opinion
The neuro-symphony of stress
Marian Joëls & Tallie Z. Baram
p459 | doi:10.1038/nrn2632
Stress induces the release of many stress mediators in the brain. Joëls and Baram show that the spatial and temporal niches of action of these mediators overlap and discuss how different mediators interact to enable appropriate responses to diverse stressors.
Correspondence
Correspondence: A rat is not a monkey is not a human: comment on Mogil (Nature Rev. Neurosci. 10, 283–294 (2009))
A. D. Craig
p466 | doi:10.1038/nrn2606-c1
