Corrigendum

Nature Reviews Neuroscience 10, 242 (March 2009) | doi:10.1038/nrn2595

Silent synapses and the emergence of a postsynaptic mechanism for LTP

Geoffrey A. Kerchner & Roger A. Nicoll

Nature Reviews Neuroscience 9, 813–825 (2008)

In the above article, an important reference was omitted and appropriate credit was not given for the first observation of silent synapses by laser-evoked glutamate uncaging on to single, visually identified dendritic spines. In the rat hippocampal CA1 region, Beique et al.1 observed thin spines that exhibited an NMDAR-mediated response at +40 mV, but no AMPAR-mediated response at -70 mV, a little over a year before a similar observation by Busetto et al.2.

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References

  1. Beique, J. C. et al. Synapse-specific regulation of AMPA receptor function by PSD-95. Proc. Natl Acad. Sci. USA 103, 19535–19540 (2006).

  2. Busetto, G., Higley, M. J. & Sabatini, B. L. Developmental presence and disappearance of postsynaptically silent synapses on dendritic spines of rat layer 2/3 pyramidal neurons. J. Physiol. 586, 1519–1527 (2008).

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