Nature Reviews Neuroscience 10, 113-125 (February 2009) | doi:10.1038/nrn2558

State-dependent computations: spatiotemporal processing in cortical networks

Dean V. Buonomano1 & Wolfgang Maass2  About the authors


A conspicuous ability of the brain is to seamlessly assimilate and process spatial and temporal features of sensory stimuli. This ability is indispensable for the recognition of natural stimuli. Yet, a general computational framework for processing spatiotemporal stimuli remains elusive. Recent theoretical and experimental work suggests that spatiotemporal processing emerges from the interaction between incoming stimuli and the internal dynamic state of neural networks, including not only their ongoing spiking activity but also their 'hidden' neuronal states, such as short-term synaptic plasticity.

Author affiliations

  1. Departments of Neurobiology and Psychology, and Brain Research Institute, University of California, Los Angeles, California 90095, USA.
  2. Institute for Theoretical Computer Science, Graz University of Technology, A-8010 Graz, Austria.

Correspondence to: Dean V. Buonomano1 Email:

Published online 15 January 2009


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