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Nature Reviews Neuroscience 10, 763 (1 November 2009) | doi:10.1038/nrn2746

Psychiatric disorders: DISC1 drives development through girdin

Katherine Whalley

Mutations in disrupted in schizophrenia 1 (DISC1) are a risk factor for multiple psychiatric and mental disorders, and DISC1 regulates diverse aspects of neuronal physiology. However, the molecular mechanisms by which DISC1 mediates its effects are largely unknown.