Nature Reviews Neuroscience 10, 736-746 (October 2009) | doi:10.1038/nrn2703

Focus on: CNS evolution

Chordate roots of the vertebrate nervous system: expanding the molecular toolkit

Linda Z. Holland1  About the author


The vertebrate brain is highly complex with millions to billions of neurons. During development, the neural plate border region gives rise to the neural crest, cranial placodes and, in anamniotes, to Rohon-Beard sensory neurons, whereas the boundary region of the midbrain and hindbrain develops organizer properties. Comparisons of developmental gene expression and neuroanatomy between vertebrates and the basal chordate amphioxus, which has only thousands of neurons and lacks a neural crest, most placodes and a midbrain–hindbrain organizer, indicate that these vertebrate features were built on a foundation already present in the ancestral chordate. Recent advances in genomics have provided insights into the elaboration of the molecular toolkit at the invertebrate–vertebrate transition that may have facilitated the evolution of these vertebrate characteristics.

Author affiliations

  1. Marine Biology Research Division, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093-0202, USA.

Published online 9 September 2009


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