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Reply — reconsolidation

The labile nature of consolidation theory

Abstract

'Consolidation' has been used to describe distinct but related processes. In considering the implications of our recent findings on the lability of reactivated fear memories, we view consolidation and reconsolidation in terms of molecular events taking place within neurons as opposed to interactions between brain regions. Our findings open up a new dimension in the study of memory consolidation. We argue that consolidation is not a one-time event, but instead is reiterated with subsequent activation of the memories.

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Acknowledgements

This research was supported in part by the National Institute of Mental Health and the Health Foundation of South Florida. The work was also supported by a grant from the W. M. Keck Foundation to New York University.

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Correspondence to Karim Nader.

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Nader, K., Schafe, G. & LeDoux, J. The labile nature of consolidation theory. Nat Rev Neurosci 1, 216–219 (2000). https://doi.org/10.1038/35044580

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