Articles in 2016

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  • It is not known how mammals sense potentially life-threatening reductions in oxygen in the ambient air, but a novel mechanism has been found in mice that involves a novel subpopulation of olfactory sensory neurons that express the soluble guanylate cyclase GUCY1β2.

    • Sian Lewis
    Research Highlight
  • Unattended information can lie latent in working memory and then be reactivated by transcranial magnetic stimulation.

    • Natasha Bray
    Research Highlight
  • Shank3deficiency disrupts TRPV1 signalling, pain processing and the induction of heat hyperalgesia in mice.

    • Katherine Whalley
    Research Highlight
  • In neurofeedback, an individual receives online feedback of their neural activity to facilitate self-regulation of a brain region and, as a result, a particular behaviour or pathology. In this Review, the authors examine how this technique has been used and its underlying mechanisms.

    • Ranganatha Sitaram
    • Tomas Ros
    • James Sulzer
    Review Article
  • Deletion ofDgcr8in 22q11.2 deletion syndrome leads to decreased processing of miR-338-3p, leading to an upregulation of thalamic dopamine D2 receptors and auditory thalamocortical deficits that might be associated with antipsychotic-sensitive auditory hallucinations.

    • Natasha Bray
    Research Highlight
  • The genetic programmes involved in axonal pruning during development are poorly elucidated but are shown to involve a balance between the anti-apoptotic protein DUSP16 and the pro-degenerative protein PUMA.

    • Sian Lewis
    Research Highlight
  • The mechanisms that underlie the transition of acute pain to a chronic intractable disorder are not well understood. In this Review, Kuner and Flor discuss how structural plasticity and reorganisation in somatosensory and emotional networks can contribute to chronic pain, integrating information available from animal models and human patients.

    • Rohini Kuner
    • Herta Flor
    Review Article
  • The anatomical complexity and location of the human subcortex render it difficult to study by MRIin vivo. Here, Forstmann et al. argue that understanding subcortex function may be facilitated by combining in vivoand post-mortem ultra-high field MRI, post-mortem histology and modelling approaches.

    • Birte U. Forstmann
    • Gilles de Hollander
    • Max C. Keuken
    Opinion
  • A brain–spine interface that uses decoded neural activity from motor cortex delivered to an electrical stimulation system in the spine was used to restore locomotor function in a monkey whose leg was paralyzed by spinal injury.

    • Sian Lewis
    Research Highlight
  • Emerging evidence suggests that astrocytes may be as diverse in their physiological and functional characteristics as neurons. Ben Haim and Rowitch describe astrocyte heterogeneity, consider the mechanisms by which such diversity may arise and discuss the consequences of its disruption in disease.

    • Lucile Ben Haim
    • David H. Rowitch
    Review Article
  • Our ability to use conceptual knowledge to support various behaviours is termed semantic cognition. In this Review, Lambon Ralphet al. argue that this ability arises from two interacting neural systems, one for representation and one for control.

    • Matthew A. Lambon Ralph
    • Elizabeth Jefferies
    • Timothy T. Rogers
    Review Article