Browse Articles

  • Comment |

    Brain implants are being trialled for their potential to ameliorate treatment-resistant conditions or to restore function. However, there are no clear guidelines for continued access to brain implants for trial participants whose symptoms improve with these devices.

    • Gabriel Lázaro-Muñoz
    • , Daniel Yoshor
    • , Michael S. Beauchamp
    • , Wayne K. Goodman
    •  & Amy L. McGuire
  • Research Highlight |

    In mice, aggression is regulated by the circadian suprachiasmatic nucleus through at least two neural pathways.

    • Natasha Bray
  • Opinion |

    The extent and contribution of maternal influence to the developing hypothalamus to later feeding behaviour remain controversial. In this Opinion, Zeltser proposes that crosstalk between developing circuits regulating different modalities of food intake shapes susceptibility to environmental challenges.

    • Lori M. Zeltser
  • Research Highlight |

    A combination of electrochemical neuromodulation of spinal leg circuits and physical training in a robotic rehabilitation system restored volitional locomotion in rodents with severe spinal cord injury.

    • Sian Lewis
  • Review Article |

    Peripheral axon injury initiates a regenerative response that is absent in CNS axons. Mahar and Cavalli describe the mechanisms that initiate and coordinate the programme of transcriptional and epigenetic changes that enable axon regeneration in the peripheral nervous system.

    • Marcus Mahar
    •  & Valeria Cavalli
  • Review Article |

    The basal ganglia and the cerebellum were thought to communicate via the cerebral cortex. In this Review, Andreea Bostan and Peter Strick discuss findings indicating that these subcortical areas are in fact interconnected and, along with the cerebral cortex, form an integrated network.

    • Andreea C. Bostan
    •  & Peter L. Strick
  • Research Highlight |

    Two studies provide insight into the neural circuits integrating competing threat signals, such as pain and hunger.

    • Katherine Whalley
  • Research Highlight |

    A study of post-mortem brains from individuals of difference ages suggests that hippocampal neurogenesis in humans decreases during childhood and is absent in adults.

    • Natasha Bray
  • Review Article |

    Fibrinogen enters the brain in a wide range of brain diseases that involve blood–brain barrier disruption. In this Review, Petersen et al. discuss recent evidence that fibrinogen causes damage that contributes to the pathology of a range of neurological disorders and discuss therapeutic implications.

    • Mark A. Petersen
    • , Jae Kyu Ryu
    •  & Katerina Akassoglou
  • Research Highlight |

    In the spinal cord and thalamus of mice, astrocyte-generated interleukin-33 instructs microglia to engulf synapses and thus regulates neural circuit development.

    • Darran Yates
  • Research Highlight |

    This study shows that human neural stem cell grafts re-establish a neuronal relay across spinal cord injury in rhesus monkeys.

    • Katharine H. Wrighton
  • Review Article |

    Advanced recording techniques have enabled the identification of travelling waves of neuronal activity in different areas of the cortex. Sejnowski and colleagues review these findings, consider the mechanisms by which travelling waves are generated and evaluate their possible roles in cortical function.

    • Lyle Muller
    • , Frédéric Chavane
    • , John Reynolds
    •  & Terrence J. Sejnowski
  • Review Article |

    The morphology of dendrites and dendritic spines changes with development and as a result of activity-dependent plasticity mechanisms. Penzes and colleagues describe the altered dendritic structural plasticity that is associated with some neuropsychiatric disorders and consider the underlying molecular mechanisms, based on recent genetic discoveries.

    • Marc P. Forrest
    • , Euan Parnell
    •  & Peter Penzes
  • Research Highlight |

    Neurons exhibiting synaptic upscaling or downscaling in response to decreases or increases in activity, respectively, show changes in protein expression that depend on the duration and the polarity of the change.

    • Natasha Bray
  • Review Article |

    Much research has shown that lactate produced by astrocytes serves as a neuronal energy substrate. In this Review, Magistretti and Allaman describe this model as well as recent evidence that lactate also modulates neuronal properties, including excitability and plasticity, thus helping to set the 'homeostatic tone' of the nervous system.

    • Pierre J. Magistretti
    •  & Igor Allaman
  • Research Highlight |

    Study employs DNA methylation editing to reactivate FMR1 expression and reverse phenotypic deficits in cells derived from individuals with fragile X syndrome.

    • Katherine Whalley
  • Research Highlight |

    Upregulated bursting activity in the lateral habenula is associated with depression-like behaviours in rats and mice, and depends on NMDA receptors, T-type voltage-sensitive calcium channels and the astrocytic inwardly rectifying potassium channel KIR4.1.

    • Natasha Bray