Jennie Vallis

Read the December issue

Including articles on remyelination, the axonal cytoskeleton, the origins of schizophrenia and the role of the dopamine motive system in addiction and obesity.

Latest Reviews

  • Review |

    The brain uses predictable temporal structure to anticipate and select relevant events in time. Nobre and van Ede introduce different types of this 'temporal expectation' and its neural underpinnings, and describe how temporal expectation interacts with other forms of expectation in guiding adaptive behaviour.

    • Anna C. Nobre
    •  & Freek van Ede
  • Progress |

    Activity-driven changes in gene transcription regulate synaptic development and function. Bading and colleagues describe recent evidence of lineage-specific changes in the gene regulatory regions that govern excitation–transcription coupling and consider how such changes may have contributed to the evolution of human cognitive abilities.

    • Giles E. Hardingham
    • , Priit Pruunsild
    • , Michael E. Greenberg
    •  & Hilmar Bading
  • Review |

    Promoting remyelination may be an effective therapeutic strategy for various disorders that are characterized by a loss of myelin, including multiple sclerosis. In this Review, Franklin and ffrench-Constant discuss recent developments in our understanding of remyelination and the efforts that are underway to enhance this process.

    • Robin J. M. Franklin
    •  & Charles ffrench-Constant
  • Review |

    The dopamine motive system, which integrates reinforcement and motivation, is influenced by obesogenic foods and addictive drugs. In this Review, Volkow and colleagues highlight how these stimuli sensitize the subject's motivation towards them while desensitizing the subject's motivation towards alternative reinforcers.

    • Nora D. Volkow
    • , Roy A. Wise
    •  & Ruben Baler
  • Opinion |

    Chemical communication between axons and their myelin sheath is an emerging concept in neurobiology. In this review, Stys and colleagues discuss how this 'axo-myelinic synapse' may play a role in metabolic control of the myelinating unit, modulate myelin dynamics and be a future therapeutic target.

    • I. Micu
    • , J. R. Plemel
    • , A. V. Caprariello
    • , K.-A. Nave
    •  & P. K. Stys
  • Review |

    An axon's function is dictated by its morphology and, thus, by the properties and organization of the axonal cytoskeleton. Leterrier et al. describe how advances in super-resolution and live-cell imaging are transforming our understanding of the molecular architecture of the axonal shaft.

    • Christophe Leterrier
    • , Pankaj Dubey
    •  & Subhojit Roy

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