Jennie Vallis

Generation of circadian rhythms in the suprachiasmatic nucleus

Latest Reviews

  • Review Article |

    Modern network neuroscience involves the use of various types of models to understand the brain. In this Review, Bassett, Zurn and Gold discuss the aims of this approach before examining how network models may be categorized and validated.

    • Danielle S. Bassett
    • , Perry Zurn
    •  & Joshua I. Gold
  • Progress |

    In recent years, several studies have reported the production of microglia-like cells from induced pluripotent stem cells. Pocock and Piers describe the methods used to produce and analyse these cells and their potential to improve our understanding of microglial function.

    • Jennifer M. Pocock
    •  & Thomas M. Piers
  • Review Article |

    Long-term episodic memory storage has been proposed to require a reorganization of neural circuits and networks in a process known as systems consolidation. Tonegawa and colleagues discuss recent advances in our understanding of the contribution of engram cells to this process.

    • Susumu Tonegawa
    • , Mark D. Morrissey
    •  & Takashi Kitamura
  • Review Article |

    Anhedonia and apathy are syndromes affecting motivation and have been reported in various neurological and psychiatric disorders. Husain and Roiser examine the neural mechanisms underlying apathy and anhedonia within a transdiagnostic framework of effort-based decision making for reward.

    • Masud Husain
    •  & Jonathan P. Roiser
  • Review Article |

    In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus acts as the principal pacemaker for circadian rhythms, which are powerful regulators of physiology and behaviour. In this Review, Hastings, Maywood and Brancaccio examine the molecular, cellular and circuit mechanisms underlying time-keeping in the SCN.

    • Michael H. Hastings
    • , Elizabeth S. Maywood
    •  & Marco Brancaccio
  • Review Article |

    The opioid system is central to addiction. Darcq and Kieffer review the role of these receptors in the addiction neurocircuitry, ask whether opioid receptors can be targeted to kill pain without addiction and discuss studies that bridge the translational gap in the field.

    • Emmanuel Darcq
    •  & Brigitte Lina Kieffer

News & Comment

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    The brains of individuals who have been addicted to opiate drugs show an increase in the number of hypocretin-expressing neurons — the same neurons that are lost in individuals with narcolepsy.

    • Natasha Bray
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    In mice, ‘lost’ infant memories can be recovered through the optogenetic reactivation of silent engrams in the hippocampus.

    • Katherine Whalley
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    A study in flies shows that projections from some groups of glomerular neurons converge on certain types of lateral horn neurons to process combinations of odours that are salient for certain behaviours.

    • Darran Yates
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    A discrete subpopulation of CA1 pyramidal cells is identified, which are distinct from place cells, that encode the location of a reward.

    • Sian Lewis
  • Research Highlight |

    A set of 80 (mostly synaptic) proteins show hyperphosphorylation in sleep-deprived mice and genetically ‘sleepy’ mice, suggesting that increased phosphorylation of such proteins may be associated with sleep need.

    • Natasha Bray
  • Research Highlight |

    In genetic fly models of Parkinson disease, disrupted lipid trafficking in neuropeptidergic neurons leads to circadian disruption.

    • Natasha Bray

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