Jennie Vallis

Signalling from the periphery to the brain that regulates energy homeostasis

Latest Reviews

  • Review |

    The morphology of dendrites and dendritic spines changes with development and as a result of activity-dependent plasticity mechanisms. Penzes and colleagues describe the altered dendritic structural plasticity that is associated with some neuropsychiatric disorders and consider the underlying molecular mechanisms, based on recent genetic discoveries.

    • Marc P. Forrest
    • , Euan Parnell
    •  & Peter Penzes
  • Review |

    Much research has shown that lactate produced by astrocytes serves as a neuronal energy substrate. In this Review, Magistretti and Allaman describe this model as well as recent evidence that lactate also modulates neuronal properties, including excitability and plasticity, thus helping to set the 'homeostatic tone' of the nervous system.

    • Pierre J. Magistretti
    •  & Igor Allaman
  • Review |

    Coordination between peripheral signals that reflect feeding status and central regulatory mechanisms are crucial for regulating body weight. In this Review, Sandoval and colleagues discuss how and where peripherally derived signals are integrated within the CNS to modulate feeding behaviour.

    • Ki-Suk Kim
    • , Randy J. Seeley
    •  & Darleen A. Sandoval
  • Review |

    How are synapses optimally strengthened or weakened to improve network performance? Roelfsema and Holtmaat provide an overview of factors that influence synaptic plasticity, particularly in deep, multilayered biological networks, and present a specific framework in which neuromodulators and feedback connections may interact to selectively potentiate synapses responsible for rewarded action.

    • Pieter R. Roelfsema
    •  & Anthony Holtmaat
  • Review |

    The human brain undergoes rapid development during the first 2 years of life. Here, Gilmore and colleagues give an overview of recent neuroimaging studies of the developmental trajectories of brain structure and function in the first years after birth.

    • John H. Gilmore
    • , Rebecca C. Knickmeyer
    •  & Wei Gao
  • Review |

    The brain regulates adipose tissue metabolism through sympathetic efferent pathways; in turn, adipose tissues relay energy-status information to the brain. This Review gives an overview of interactions between the brain and adipose tissues, with a particular focus on leptin as a regulator of these communications.

    • Alexandre Caron
    • , Syann Lee
    • , Joel K. Elmquist
    •  & Laurent Gautron

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