Nature Reviews Microbiology 9, 817-828 (November 2011) | doi:10.1038/nrmicro2667

Non-transcriptional regulatory processes shape transcriptional network dynamics

J. Christian J. Ray1,2, Jeffrey J. Tabor1 & Oleg A. Igoshin1  About the authors


Information about the extra- or intracellular environment is often captured as biochemical signals that propagate through regulatory networks. These signals eventually drive phenotypic changes, typically by altering gene expression programmes in the cell. Reconstruction of transcriptional regulatory networks has given a compelling picture of bacterial physiology, but transcriptional network maps alone often fail to describe phenotypes. Cellular response dynamics are ultimately determined by interactions between transcriptional and non-transcriptional networks, with dramatic implications for physiology and evolution. Here, we provide an overview of non-transcriptional interactions that can affect the performance of natural and synthetic bacterial regulatory networks.

Author affiliations

  1. Department of Bioengineering, Rice University, 6100 Main St., Houston, Texas 77005, USA.
  2. Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

Correspondence to: Oleg A. Igoshin1 Email:

Published online 11 October 2011