Table of contents
In this issue
p321 | doi:10.1038/nrmicro2139
Editorial: Malaria: health is wealth
p322 | doi:10.1038/nrmicro2144
Research Highlights
Bacterial physiology: Ahead of the curve | PDF (236 KB)
p323 | doi:10.1038/nrmicro2135
Evolution: Good mutations available in all sizes | PDF (158 KB)
p324 | doi:10.1038/nrmicro2134
In brief
Industrial Microbiology | Parasitology | Bacterial physiology | PDF (131 KB)
p324 | doi:10.1038/nrmicro2138
Viral immune evasion: Interferon interference | PDF (188 KB)
p325 | doi:10.1038/nrmicro2140
Bacterial physiology: OppA's deep pockets | PDF (198 KB)
p325 | doi:10.1038/nrmicro2141
Bacterial Pathogenesis: Making a niche | PDF (222 KB)
p326 | doi:10.1038/nrmicro2132
Bacterial ecology: Cheaters get eaten | PDF (171 KB)
p326 | doi:10.1038/nrmicro2142
Bacterial Chromosomes: Pol III picks up the pieces | PDF (572 KB)
p327 | doi:10.1038/nrmicro2136
News and Analysis
Genome watch
Genome Watch: Breaking the ICE | PDF (203 KB)
p328 | doi:10.1038/nrmicro2137
Disease watch
In the News | PDF (430 KB)
p330 | doi:10.1038/nrmicro2143
Focus on: Microbial Host Cell Subversion
Reviews
Life on the inside: the intracellular lifestyle of cytosolic bacteria
Katrina Ray, Benoit Marteyn, Philippe J. Sansonetti & Christoph M. Tang
p333 | doi:10.1038/nrmicro2112
Many bacterial pathogens can invade non-phagocytic cells and survive within a membrane-bound vacuole. However, few pathogens are able to escape the vacuoles and proliferate in the host cell cytosol. In this Review, Tang and colleagues discuss the mechanisms by which these pathogens enter the cytosol, obtain nutrients and subvert host immune responses.
Malaria parasite proteins that remodel the host erythrocyte
Alexander G. Maier, Brian M. Cooke, Alan F. Cowman & Leann Tilley
p341 | doi:10.1038/nrmicro2110
The malaria parasite exports an array of proteins while it resides in the erythrocytes of its host. This Review describes the functions of parasite proteins that interact with the erythrocyte membrane skeleton or that promote delivery of the major virulence protein, PfEMP1, to the erythrocyte membrane.
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies
Ronald S. Flannagan, Gabriela Cosío & Sergio Grinstein
p355 | doi:10.1038/nrmicro2128
The host cell and intracellular pathogens are in a continuous struggle. Flannagan, Cosío and Grinstein describe the pathway by which the bacteria are taken up, the antimicrobial mechanisms of the host cell and the different ways bacteria evade these mechanisms.
Perspectives
Opinion
Do symbiotic bacteria subvert host immunity?
Lora V. Hooper
p367 | doi:10.1038/nrmicro2114
The mammalian intestine is colonized by complex indigenous bacterial communities that establish beneficial symbiotic relationships with their host, making important contributions to host metabolism and digestive efficiency. In this Opinion article, Lora Hooper explores the roles of immune suppression, evasion and subversion in the establishment of these important symbiotic relationships.
Progress
Exoelectrogenic bacteria that power microbial fuel cells
Bruce E. Logan
p375 | doi:10.1038/nrmicro2113
The use of microbial fuel cells to generate electrical current is increasingly being seen as a viable source of renewable energy production. In this Progress article, Bruce Logan highlights recent advances in our understanding of the mechanisms used by exoelectrogenic bacteria to generate electrical current and the important factors to consider in microbial fuel cell design.
Reviews
Article series: Systems Microbiology
Using movies to analyse gene circuit dynamics in single cells
James C. W. Locke & Michael B. Elowitz
p383 | doi:10.1038/nrmicro2056
Movies, made possible by the combination of time-lapse microscopy, quantitative image analysis and fluorescent protein reporters, are allowing us to directly observe various cellular components over time in individual cells. As such, movies are providing powerful insights into the behaviour of genetic circuit behaviours in diverse microbial systems.
Correlates of protective immunity for Ebola vaccines: implications for regulatory approval by the animal rule
Nancy J. Sullivan, Julie E. Martin, Barney S. Graham & Gary J. Nabel
p393 | doi:10.1038/nrmicro2129
For diseases that are both rare and lethal, it is difficult to test vaccines. Sullivan and colleagues describe the use of immune correlates and the animal rule for the licensing of Ebola vaccines.
There is a Corrigendum (15 July 2009) associated with this article.
