Perspectives

Nature Reviews Microbiology 7, 367-374 (May 2009) | doi:10.1038/nrmicro2114

Focus on: Microbial Host Cell Subversion

OpinionDo symbiotic bacteria subvert host immunity?

Lora V. Hooper1  About the author

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The mammalian intestine is home to dense and complex indigenous bacterial communities. Most of these bacteria establish beneficial symbiotic relationships with their hosts, making important contributions to host metabolism and digestive efficiency. The vast numbers of intestinal bacteria and their proximity to host tissues raise the question of how symbiotic host–bacterial relationships are established without eliciting potentially harmful immune responses. In light of the varied ways in which pathogenic bacteria manipulate host immunity, this Opinion article explores the role of immune suppression, subversion and evasion in the establishment of symbiotic host–bacterial associations.

Author affiliations

  1. Howard Hughes Medical Institute, Department of Immunology and Department of Microbiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Email: lora.hooper@utsouthwestern.edu

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