Perspectives
Nature Reviews Microbiology 7, 297-305 (April 2009) | doi:10.1038/nrmicro2107
Article series: Systems Microbiology
Opinion: The role of predictive modelling in rationally re-engineering biological systems
Tie Koide1, Wyming Lee Pang1 & Nitin S. Baliga1,2 About the authors
Abstract
Technologies to synthesize and transplant a complete genome into a cell have opened limitless potential to redesign organisms for complex, specialized tasks. However, large-scale re-engineering of a biological circuit will require systems-level optimization that will come from a deep understanding of operational relationships among all the constituent parts of a cell. The integrated framework necessary for conducting such complex bioengineering requires the convergence of systems and synthetic biology. Here, we review the status of these rapidly developing interdisciplinary fields of biology and provide a perspective on plausible venues for their merger.
Author affiliations
- Tie Koide, Wyming Lee Pang and Nitin S. Baliga are at the Institute for Systems Biology, 1441 N 34th Street, Seattle, Washington 98103, USA.
- Nitin S. Baliga is also at the Departments of Microbiology, and Molecular and Cellular Biology, University of Washington, Seattle, Washington 98195, USA.
Correspondence to: Nitin S. Baliga1,2 Email: nbaliga@systemsbiology.org
Published online 2 March 2009
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