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Research Highlights
Nature Reviews Microbiology 7, 840 (1 December 2009) | doi:10.1038/nrmicro2263
HIV: No place to hide
Abstract
Although highly active antiretroviral therapy (HAART) can reduce viral load below detectable levels, it cannot cure HIV-1 infection, owing to the presence of a reservoir of latent integrated HIV-1 proviruses in resting CD4+ T cells. Coupling the reactivation of this viral reservoir with HAART could provide a way to purge infection completely.
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