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Nature Reviews Microbiology 7, 764 (1 November 2009) | doi:10.1038/nrmicro2257

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CEACAM6 and Crohn's Disease Investigators have found that expression of human carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) makes mice susceptible to infection by adhesive and invasive Escherichia coli (AIEC), which has been linked to Crohn's disease in humans. Crohn's disease is thought to be caused either by normal gut microbiota, in response to misexpressed CEACAM6 in the gut, or by changes in the gut flora.