Perspectives
Nature Reviews Microbiology 6, 699-708 (September 2008) | doi:10.1038/nrmicro1928
Opinion: Architects of assembly: roles of Flaviviridae non-structural proteins in virion morphogenesis
Catherine L. Murray1, Christopher T. Jones1 & Charles M. Rice1 About the authors
Abstract
Viruses of the Flaviviridae family, including hepatitis C, dengue and bovine viral diarrhoea, are responsible for considerable morbidity and mortality worldwide. Recent advances in our understanding of virion assembly have uncovered commonalities among distantly related members of this family. We discuss the emerging hypothesis that physical virion components are not alone in forming the infectious particle, but that non-structural proteins are intimately involved in orchestrating morphogenesis. Pinpointing the roles of Flaviviridae proteins in virion production could reveal new avenues for antiviral therapeutics.
Author affiliations
- Catherine L. Murray, Christopher T. Jones and Charles M. Rice are at The Rockefeller University, 1230 York Avenue, BOX 64, New York, New York 10065, USA.
Correspondence to: Catherine L. Murray1Charles M. Rice1 Email: ricec@mail.rockefeller.edu
Published online 30 June 2008
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Structures of immature flavivirus particlesThe EMBO Journal Article (01 Jun 2003)
Structures of immature flavivirus particlesThe EMBO Journal Article (01 Jun 2003)
See all 10 matches for Research
