Abstract

The flagellar pocket (FP) of the protozoan parasite Trypanosoma brucei, the cause of sleeping sickness, is an important organelle that is formed by the invagination of the plasma membrane and is sequestered in the cytoplasm of the posterior region of the cell. As well as being the site where the single flagellum is located, both endocytosis and exocytosis occur exclusively through the FP and it has a crucial role in immune evasion during infection.