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Nature Reviews Microbiology 6, 394–401 (1 May 2008) | doi:10.1038/nrmicro1853
Searching for the cause of Kawasaki disease |[mdash]| cytoplasmic inclusion bodies provide new insight
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Abstract
Kawasaki disease (KD) has emerged as the most common cause of acquired heart disease in children in the developed world. The cause of KD remains unknown, although an as-yet unidentified infectious agent might be responsible. By determining the causative agent, we can improve diagnosis, therapy and prevention of KD. Recently, identification of an antigen-driven IgA response that was directed at cytoplasmic inclusion bodies in KD tissues has provided new insights that could unlock the mysteries of KD.
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