Perspectives
Nature Reviews Microbiology 6, 394-401 (May 2008) | doi:10.1038/nrmicro1853
Opinion: Searching for the cause of Kawasaki disease — cytoplasmic inclusion bodies provide new insight
Anne H. Rowley1, Susan C. Baker2, Jan M. Orenstein3 & Stanford T. Shulman1 About the authors
Abstract
Kawasaki disease (KD) has emerged as the most common cause of acquired heart disease in children in the developed world. The cause of KD remains unknown, although an as-yet unidentified infectious agent might be responsible. By determining the causative agent, we can improve diagnosis, therapy and prevention of KD. Recently, identification of an antigen-driven IgA response that was directed at cytoplasmic inclusion bodies in KD tissues has provided new insights that could unlock the mysteries of KD.
Author affiliations
- Anne H. Rowley and Stanford T. Shulman are at the Departments of Pediatrics and Microbiology/Immunology, Northwestern University Feinberg School of Medicine, The Center for Kawasaki Disease, The Children's Memorial Hospital, Chicago, 60611 Illinois, USA.
- Susan C. Baker is at the Department of Microbiology/Immunology, Loyola University Stritch School of Medicine, Maywood, 60153, Illinois, USA.
- Jan M. Orenstein is at the Department of Pathology, George Washington University School of Medicine, 20037, Washington DC, USA.
Correspondence to: Anne H. Rowley1 Email: a-rowley@northwestern.edu
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