Table of contents
May 2008 Vol 6 No 5
In this issue
p327 | doi:10.1038/nrmicro1894
Editorial: Networking for infectious disease
p328 | doi:10.1038/nrmicro1896
Research Highlights
Host response: Innate mimicry | PDF (457 KB)
p329 | doi:10.1038/nrmicro1903
Environmental microbiology: A drop in the ocean | PDF (337 KB)
p330 | doi:10.1038/nrmicro1902
Fungal biology: Breaking the mould? | PDF (390 KB)
p330 | doi:10.1038/nrmicro1904
Bacterial physiology: Double trouble | PDF (247 KB)
p331 | doi:10.1038/nrmicro1897
Host response: Deadly perfume | PDF (278 KB)
p332 | doi:10.1038/nrmicro1905
Symbiosis: Show me the sugar | PDF (425 KB)
p332 | doi:10.1038/nrmicro1908
In brief
Environmental microbiology | Malaria | PDF (96 KB)
p333 | doi:10.1038/nrmicro1906
Retroviruses: Integration hotspots for disease? | PDF (181 KB)
p333 | doi:10.1038/nrmicro1907
News and Analysis
Genome watch: Overtake in reverse gear | PDF (682 KB)
p334 | doi:10.1038/nrmicro1898
Disease watch
In the News | PDF (674 KB)
p336 | doi:10.1038/nrmicro1909
Reviews
Single-cell identification in microbial communities by improved fluorescence in situ hybridization techniques
Rudolf Amann & Bernhard M. Fuchs
p339 | doi:10.1038/nrmicro1888
Amann and Fuchs provide an update on recent methodological improvements to fluorescence in situ hybridization protocols, with a particular focus on whether the original group-specific probes, which were mostly developed more than 10 years ago, are still valid.
Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria
Jerry M. Wells & Annick Mercenier
p349 | doi:10.1038/nrmicro1840
The development of lactic acid bacteria as delivery vehicles for therapeutics, anti-infectives and vaccines at mucosa is discussed in this Review. Engineered LAB could be deployed to treat conditions such as allergy and inflammatory bowel disease, and might also be adopted in the fight against pathogens, including HIV-1 infection.
Modification of intracellular membrane structures for virus replication
Sven Miller & Jacomine Krijnse-Locker
p363 | doi:10.1038/nrmicro1890
Many viruses induce the formation of altered membrane structures upon replication in host cells. This Review examines how viruses modify intracellular membranes, highlights similarities between the structures that are induced by viruses from different families and discusses how these structures could be formed.
Emerging and re-emerging rickettsioses: endothelial cell infection and early disease events
David H. Walker & Nahed Ismail
p375 | doi:10.1038/nrmicro1866
Rickettsiae are obligate parasites that cause sometimes deadly human infections, including epidemic typhus and Rocky Mountain spotted fever. David Walker and Nahed Ismail review the early and late events in pathogenesis and immunity, including virulence mechanisms and rickettsial manipulation of host cells.
Perspectives
Opinion
Genomic fluidity and pathogenic bacteria: applications in diagnostics, epidemiology and intervention
Niyaz Ahmed, Ulrich Dobrindt, Jörg Hacker & Seyed E. Hasnain
p387 | doi:10.1038/nrmicro1889
DNA acquisition and loss have important roles in bacterial genome evolution. Jörg Hacker and colleagues look at how this genomic fluidity can be harnessed in the development of new diagnostics and molecular epidemiological methods.
Opinion
Searching for the cause of Kawasaki disease — cytoplasmic inclusion bodies provide new insight
Anne H. Rowley, Susan C. Baker, Jan M. Orenstein & Stanford T. Shulman
p394 | doi:10.1038/nrmicro1853
Although Kawasaki disease (KD) is the most common cause of acquired heart disease in children in the developed world, its aetiology remains unknown. In this Opinion, Anne Rowley and colleagues discuss evidence, including recently identified cytoplasmic inclusion bodies, which suggests that KD is caused by an infectious agent.
Timeline
Making a difference: 30 years of TDR
Robert G. Ridley & Elaine R. Fletcher
p401 | doi:10.1038/nrmicro1899
Robert Ridley and Elaine Fletcher review the past 30 years of activity by TDR and the key achievements of the programme in tropical-disease research.
Correspondence
Correspondence: Diatoms in a future ocean — stirring it up
Francesc Peters
p407 | doi:10.1038/nrmicro1751-c1
Correspondence: Diatoms in a future ocean — stirring it up: reply from Falkowski and Oliver
Paul G. Falkowski & Matthew J. Oliver
p407 | doi:10.1038/nrmicro1751-c2
Erratum: Sociomicrobiology: The evolution of quorum sensing in bacterial biofilms
p408 | doi:10.1038/nrmicro1891